Funded Projects
Gene Therapy – UT Southwestern Medical Center (UTSW)
Supporting groundbreaking gene therapy research at UT Southwestern, exploring innovative ways to address the underlying genetic cause of the condition and bring us closer to potential treatments.
Archie's Embrace has an ongoing relationship with UTSW
VIVAN Therapeutics – Drug Repurposing Project
VIVAN Therapeutics explored whether existing, approved medications could be repurposed to help treat ECHS1. Using innovative disease models and drug screening, the project aimed to identify potential treatment options that might otherwise be overlooked.
Archie's Embrace contributed 10,000 Euros
La Trobe University – ECHS1 Research (Associate Professor Travis Johnson)
Archie's Embrace funded $138,545 in research led by Associate Professor Travis Johnson and Dr Sarah Mele at La Trobe University, using genetically modified fruit flies to model ECHS1 deficiency and investigate how the condition affects metabolism. The research found that restricting the amino acid valine extended survival in the fruit fly model, providing an important breakthrough in understanding how dietary changes may help manage the condition. This work is helping guide further research into potential dietary and therapeutic treatments for children living with ECHS1 deficiency.
What's Next .....
Mount Sinai - New York
We have an exciting opportunity to fund a proposed project to create iPSC cell lines and ECHS1 brain organoids (mini models of brain tissue) that hopes to be used to study the disease and potential therapies.
LaTrobe University _ Childhood Dementia
Childhood dementia is the collective term for over 100 conditions that are devastating for children and their families. They can gradually take away a child’s ability to speak, move, recognise loved ones and participate in everyday life.
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Gene Therapy – UT Southwestern Medical Center (UTSW)
Supporting groundbreaking gene therapy research at UT Southwestern, exploring innovative ways to address the underlying genetic cause of the condition and bring us closer to potential treatments.
Archie's Embrace has an ongoing relationship with UTSW